Since its discovery in the early 1980s, the spread of the acquired immune deficiency syndrome (AIDS) has taken pandemic proportions. At present, an estimated 40 million people are living with HIV/AIDS. As a result, AIDS is one of the ten main causes of death in the World. TRIoH focusses on the HIV virus and the Consortium was created around this topic under the EU Commission, Sixth Framework Programme for Life sciences, genomics and biotechnology for health.

TRIoH's main objective is to integrate different research efforts from different European partners on novel anti-HIV molecules targeting viral replication and integration. Our central scientific paradigm is the molecular continuum between the different HIV early replication steps starting with viral entry and leading to integration.

We will use multidisciplinary proteomics approaches to study the basic science of HIV replication and integration. There is special focus on the identification of new, cellular host factors. Our research will foster a technological platform of academic and industrial partners and result in more efficient development of new drugs and therapies by providing new assays and new targets. Basic science, biotechnology and provocative chemistry will guide the development of new HIV therapeutics. Identified lead compounds of participating partners will be developed preclinically, ready for Phase 1 clinical trials.

Different Biotech SMEs are actively involved in the development and valorisation program. Drug development will include all aspects of present day drug development: chemical synthesis, drug evalation in enzymatic and cell culture assays, modelling and co-crystallisation, mechanism of action studies including biophysical measurements, antiviral resistance development and analysis, toxicological and pharmacological evaluation in cell culture and animal models.

 

 

 

 

Copyright © Katholieke Universiteit Leuven | reacties op de inhoud: Peter Bogaerts
Realisatie: Bruno Hoste| Laatste wijziging: 21-06-2007
URL: http://www.kuleuven.be/molvirgen/projects/trioh/indextr.htm

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TRIoH

TRIoH

Targeting Replication and Integration of HIV

Application of knowledge and technologies in the field of genomics and biotechnology for health

FP6