| Person in charge of the project: |
An orthogonal episome: an artificial genetic system based on novel type of nucleic acids.
|
|
Information storage and propagation in biological systems is based on just two types of nucleic acids, DNA and RNA. Our aim is to design and build artificial genetic systems based on alternative nucleic acid architectures and "invade" biological information processing with an orthologous autonomously replicating episome (which we nage the "orthosome"). We propose to build the orthosome from sugar modified oligonucleotides HNA (hexitol nucleic acids) and CeNA (cyclohexene nucleic acids) because of their conformational analogy, helix forming properties and resistance to enzymatic degradation.
|
| |
Project number:
3M060323
Duration of the project:
01.01.2006 - 31.12.2008
Funded research
Nederlands
|
